Treatment of idiopathic Parkinson’s disease is mainly symptomatic treatment with dopaminergic therapy. Complications of chronic dopaminergic treatment including motor and nonmotor fluctuations become major problems experienced by patients. Thai Parkinson’s disease and movement disorders society (Thai-PDMDS) has developed an application in Thai language (text and voice) for tablets and smart phones to detect wearing-off (WO) in Parkinson’s disease patients, but never before validated as a tool for diagnosis of WO.
